{"id":52,"date":"2025-10-14T21:06:26","date_gmt":"2025-10-14T21:06:26","guid":{"rendered":"http:\/\/zhenghanlab.com\/wordpress\/?p=52"},"modified":"2025-10-14T21:06:26","modified_gmt":"2025-10-14T21:06:26","slug":"new-publication-about-mri-mpi-tracking-of-stem-cell-derived-extracellular-vesicles-at-journal-of-extracellular-vesicles","status":"publish","type":"post","link":"http:\/\/zhenghanlab.com\/wordpress\/index.php\/2025\/10\/14\/new-publication-about-mri-mpi-tracking-of-stem-cell-derived-extracellular-vesicles-at-journal-of-extracellular-vesicles\/","title":{"rendered":"New publication about MRI\/MPI tracking of Stem-cell-derived Extracellular vesicles at Journal of Extracellular Vesicles"},"content":{"rendered":"\n<p>Title: Magnetically Labelled iPSC-Derived Extracellular Vesicles Enable MRI\/MPI-Guided Regenerative Therapy for Myocardial Infarction:<a href=\"https:\/\/doi.org\/10.1002\/jev2.70178\">https:\/\/doi.org\/10.1002\/jev2.70178<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/media.licdn.com\/dms\/image\/v2\/D4E22AQEbx860BvVzGg\/feedshare-shrink_800\/B4EZnKTl.SGcAs-\/0\/1760035760377?e=1763596800&amp;v=beta&amp;t=_MFQnp9DRw3IawLqnyTAjcAQxZbDDI9BCvBEF6DB7_M\" alt=\"\"\/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"d9608128\">ABSTRACT<\/h2>\n\n\n\n<p>Stem cell-derived extracellular vesicles (EVs) offer a promising cell-free approach for cardiovascular regenerative medicine. In this study, we developed magnetically labelled induced pluripotent stem cell-derived EVs (magneto-iPSC-EVs) encapsulated with superparamagnetic iron oxide (SPIO) nanoparticles for image-guided regenerative treatment of myocardial infarction, in which EVs that can be detected by both magnetic resonance imaging (MRI) and magnetic particle imaging (MPI). iPSC-EVs were isolated, characterized per MISEV2023 guidelines, and loaded with SuperSPIO20 nanoparticles using optimized electroporation conditions (300&nbsp;V, 2 \u00d7 10&nbsp;ms pulses), achieving a high loading efficiency of 1.77&nbsp;ng Fe\/10<sup>6<\/sup>&nbsp;EVs. In vitro results show that magneto-iPSC-EVs can be sensitively detected by MPI and MRI, with a detectability of approximately 10<sup>7<\/sup>&nbsp;EVs. In a mouse myocardial ischemia-reperfusion model, intramyocardially injected magneto-iPSC-EVs (2 \u00d7 10<sup>9<\/sup>) were imaged non-invasively by in vivo MPI for 7 days and ex vivo MRI, with the presence of magneto-iPSC-EVs confirmed by Prussian blue staining. Therapeutically, both native and magneto- iPSC-EVs significantly improved cardiac function, with a 37.3% increase in left ventricular ejection fraction and 61.0% reduction in scar size. This study highlights the potential of magneto-iPSC-EVs as a cell-free approach for cardiovascular regenerative medicine, offering both non-invasive imaging capabilities and therapeutic benefits for myocardial repair.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Title: Magnetically Labelled iPSC-Derived Extracellular Vesicles Enable MRI\/MPI-Guided Regenerative Therapy for Myocardial Infarction:https:\/\/doi.org\/10.1002\/jev2.70178 ABSTRACT Stem cell-derived extracellular vesicles (EVs) offer a promising cell-free approach for cardiovascular regenerative medicine. In this study, we developed magnetically labelled induced pluripotent stem cell-derived EVs (magneto-iPSC-EVs) encapsulated with superparamagnetic iron oxide (SPIO) nanoparticles for image-guided regenerative treatment of myocardial infarction, &hellip; <a href=\"http:\/\/zhenghanlab.com\/wordpress\/index.php\/2025\/10\/14\/new-publication-about-mri-mpi-tracking-of-stem-cell-derived-extracellular-vesicles-at-journal-of-extracellular-vesicles\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;New publication about MRI\/MPI tracking of Stem-cell-derived Extracellular vesicles at Journal of Extracellular Vesicles&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-52","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New publication about MRI\/MPI tracking of Stem-cell-derived Extracellular vesicles at Journal of Extracellular Vesicles - Zheng Han Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/zhenghanlab.com\/wordpress\/index.php\/2025\/10\/14\/new-publication-about-mri-mpi-tracking-of-stem-cell-derived-extracellular-vesicles-at-journal-of-extracellular-vesicles\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New publication about MRI\/MPI tracking of Stem-cell-derived Extracellular vesicles at Journal of Extracellular Vesicles - Zheng Han Lab\" \/>\n<meta property=\"og:description\" content=\"Title: Magnetically Labelled iPSC-Derived Extracellular Vesicles Enable MRI\/MPI-Guided Regenerative Therapy for Myocardial Infarction:https:\/\/doi.org\/10.1002\/jev2.70178 ABSTRACT Stem cell-derived extracellular vesicles (EVs) offer a promising cell-free approach for cardiovascular regenerative medicine. In this study, we developed magnetically labelled induced pluripotent stem cell-derived EVs (magneto-iPSC-EVs) encapsulated with superparamagnetic iron oxide (SPIO) nanoparticles for image-guided regenerative treatment of myocardial infarction, &hellip; Continue reading &quot;New publication about MRI\/MPI tracking of Stem-cell-derived Extracellular vesicles at Journal of Extracellular Vesicles&quot;\" \/>\n<meta property=\"og:url\" content=\"http:\/\/zhenghanlab.com\/wordpress\/index.php\/2025\/10\/14\/new-publication-about-mri-mpi-tracking-of-stem-cell-derived-extracellular-vesicles-at-journal-of-extracellular-vesicles\/\" \/>\n<meta property=\"og:site_name\" content=\"Zheng Han Lab\" \/>\n<meta property=\"article:published_time\" content=\"2025-10-14T21:06:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/media.licdn.com\/dms\/image\/v2\/D4E22AQEbx860BvVzGg\/feedshare-shrink_800\/B4EZnKTl.SGcAs-\/0\/1760035760377?e=1763596800&amp;v=beta&amp;t=_MFQnp9DRw3IawLqnyTAjcAQxZbDDI9BCvBEF6DB7_M\" \/>\n<meta name=\"author\" content=\"zhenghan\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"zhenghan\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"http:\/\/zhenghanlab.com\/wordpress\/index.php\/2025\/10\/14\/new-publication-about-mri-mpi-tracking-of-stem-cell-derived-extracellular-vesicles-at-journal-of-extracellular-vesicles\/#article\",\"isPartOf\":{\"@id\":\"http:\/\/zhenghanlab.com\/wordpress\/index.php\/2025\/10\/14\/new-publication-about-mri-mpi-tracking-of-stem-cell-derived-extracellular-vesicles-at-journal-of-extracellular-vesicles\/\"},\"author\":{\"name\":\"zhenghan\",\"@id\":\"http:\/\/zhenghanlab.com\/wordpress\/#\/schema\/person\/977e914bbbde262c12a99ff68763725c\"},\"headline\":\"New publication about MRI\/MPI tracking of Stem-cell-derived Extracellular vesicles at Journal of Extracellular Vesicles\",\"datePublished\":\"2025-10-14T21:06:26+00:00\",\"dateModified\":\"2025-10-14T21:06:26+00:00\",\"mainEntityOfPage\":{\"@id\":\"http:\/\/zhenghanlab.com\/wordpress\/index.php\/2025\/10\/14\/new-publication-about-mri-mpi-tracking-of-stem-cell-derived-extracellular-vesicles-at-journal-of-extracellular-vesicles\/\"},\"wordCount\":227,\"commentCount\":0,\"publisher\":{\"@id\":\"http:\/\/zhenghanlab.com\/wordpress\/#\/schema\/person\/977e914bbbde262c12a99ff68763725c\"},\"image\":{\"@id\":\"http:\/\/zhenghanlab.com\/wordpress\/index.php\/2025\/10\/14\/new-publication-about-mri-mpi-tracking-of-stem-cell-derived-extracellular-vesicles-at-journal-of-extracellular-vesicles\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/media.licdn.com\/dms\/image\/v2\/D4E22AQEbx860BvVzGg\/feedshare-shrink_800\/B4EZnKTl.SGcAs-\/0\/1760035760377?e=1763596800&amp;v=beta&amp;t=_MFQnp9DRw3IawLqnyTAjcAQxZbDDI9BCvBEF6DB7_M\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"http:\/\/zhenghanlab.com\/wordpress\/index.php\/2025\/10\/14\/new-publication-about-mri-mpi-tracking-of-stem-cell-derived-extracellular-vesicles-at-journal-of-extracellular-vesicles\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"http:\/\/zhenghanlab.com\/wordpress\/index.php\/2025\/10\/14\/new-publication-about-mri-mpi-tracking-of-stem-cell-derived-extracellular-vesicles-at-journal-of-extracellular-vesicles\/\",\"url\":\"http:\/\/zhenghanlab.com\/wordpress\/index.php\/2025\/10\/14\/new-publication-about-mri-mpi-tracking-of-stem-cell-derived-extracellular-vesicles-at-journal-of-extracellular-vesicles\/\",\"name\":\"New publication about MRI\/MPI tracking of Stem-cell-derived Extracellular vesicles at Journal of Extracellular Vesicles - 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In this study, we developed magnetically labelled induced pluripotent stem cell-derived EVs (magneto-iPSC-EVs) encapsulated with superparamagnetic iron oxide (SPIO) nanoparticles for image-guided regenerative treatment of myocardial infarction, &hellip; Continue reading \"New publication about MRI\/MPI tracking of Stem-cell-derived Extracellular vesicles at Journal of Extracellular Vesicles\"","og_url":"http:\/\/zhenghanlab.com\/wordpress\/index.php\/2025\/10\/14\/new-publication-about-mri-mpi-tracking-of-stem-cell-derived-extracellular-vesicles-at-journal-of-extracellular-vesicles\/","og_site_name":"Zheng Han 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